Coronary heart disease (CHD) is the leading cause of death both in the UK and worldwide. CHD generally affects more men than women, but both are at higher risk as age increases. The disease occurs when there is a build-up of fatty substances, especially LDL cholesterol, in the lining of the coronary arteries causing them to become narrower. This is known as atherosclerosis.
There are many symptoms related to this disease such as angina, which is severe pain in the chest as little oxygen-rich blood is being delivered to the heart, hypertension which is associated with a high blood pressure, and myocardial infarction (heart attack). The Epiomic™ database sub-divides the patient population into these various symptoms to see which are most common in CHD sufferers, giving a deeper insight into the illness.
There are also many risk factors affiliated with CHD such as smoking, high cholesterol diets, high blood pressure, diabetes and obesity. Although there is no cure for CHD, there are a range of treatments to help manage the symptoms including statins, beta-blockers and anti-platelets. Scientists are striving continually to improve their understanding of how atherosclerosis develops and the role of risk factors, in order to develop new therapies. The Epiomic™ database provides companies with robust information about the relationship between risk factors and sufferers of CHD by sub-dividing the patient population based on BMI, cholesterol levels, smoking, diabetes, blood pressure (diastolic and systolic) and obesity.